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	Provedor de dados International Journal of Morphology (3) Autor Barbosa-da-Silva,Sandra (3) Aguila,Marcia Barbosa (2) Mandarim-de-Lacerda,Carlos Alberto (2) Bargut,Thereza C. Lonzetti (1) Carvallo,Eugenia (1) Carvallo,Pamela (1) Lannes,Wilian Rodrigues (1) Mandarim-de-Lacerda,Carlos A (1) Miranda,Andressa Cabral de (1) Sarmento,Isabele Bringhenti (1) Souza-Mello,Vanessa (1) Souza-Mello,Vanessa de (1) del Sol,Mariano (1) Mais... Palavra-chave Animal models (1) Beta-oxidation (1) Esteatohepatitis no alcohólica (1) Fibrosis hepática (1) Fructosa (1) Hepatic lipogenesis (1) High-fat diet (1) Hígado graso no alcohólico (1) Maternal obesity (1) Metabolic disease (1) Nutritional induction (1) Offspring (1) Type 2 diabetes mellitus (1) Mais... Tipo do documento Journal article (3) Ano 2017 (1) 2015 (1) 2014 (1) País Chile (3) Idioma Inglês (2) Espanhol (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Animal Models of Nutritional Induction of Type 2 Diabetes Mellitus International Journal of Morphology Barbosa-da-Silva,Sandra; Sarmento,Isabele Bringhenti; Bargut,Thereza C. Lonzetti; Souza-Mello,Vanessa; Aguila,Marcia Barbosa; Mandarim-de-Lacerda,Carlos A. Type 2 diabetes mellitus (DM2) is the most common chronic metabolic disease, affecting approximately 6% of the adult population in the Western world. This condition is a major cause of cardiovascular disease, blindness, renal failure, and amputations, with increasing prevalence worldwide. The inuence of obesity on type 2 diabetes risk is determined by the degree of obesity and by body fat localization, with insulin resistance (IR) being the main link between these metabolic diseases. Experimental studies have shown that dietary factors, and particularly lipids, are strongly positively associated with body mass (BM) gain; IR; and, consequently, type 2 diabetes. Similarly, excessive consumption of energy-dense carbohydrate-rich foods can trigger the onset of... Tipo: Journal article Palavras-chave: Animal models; Nutritional induction; Metabolic disease; Type 2 diabetes mellitus. Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000100046 Both Hepatic Lipogenesis and Beta-Oxidation are Altered in Offspring of Mothers Fed a High-Fat Diet in the First Two Generations (F1 and F2) International Journal of Morphology Lannes,Wilian Rodrigues; Miranda,Andressa Cabral de; Souza-Mello,Vanessa de; Barbosa-da-Silva,Sandra; Aguila,Marcia Barbosa; Mandarim-de-Lacerda,Carlos Alberto. The high fat (HF) fed mothers may program susceptibility in offspring to chronic diseases and affect subsequent generations. The present study evaluated the liver structure in adulthood, focusing on the F1 and F2 generations. Females C57BL/6 (F0) were fed standard chow (SC) or HF diet (8 weeks) prior to mating and during the gestation and lactation to provide the F1 generation (SC-F1 and HF-F1). All other mothers and offspring fed SC. At 3 months old, F1 females were mated to produce the F2 generation (SC-F2 and HF-F2). The liver was kept in several fragments and prepared for histological analysis or frozen for biochemical and molecular analyzes. The F1 and F2 offspring were studied at 3 months old. HF-F1 had higher body mass (BM) compared to SC-F1 (P=... Tipo: Journal article Palavras-chave: High-fat diet; Hepatic lipogenesis; Beta-oxidation; Maternal obesity; Offspring. Ano: 2015 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000400052 NAFLD e Ingesta de Fructosa en Altas concentraciones: Una Revisión de la Literatura International Journal of Morphology Carvallo,Pamela; Carvallo,Eugenia; Barbosa-da-Silva,Sandra; Mandarim-de-Lacerda,Carlos Alberto; del Sol,Mariano. Uno de los endulzantes más comúnmente utilizado es la fructosa. La fructosa es directamente metabolizada en el hígado y se puede transformar en glucosa, posteriormente es almacenada como glicógeno constituyéndose en una fuente de energía para los hepatocitos. Todo el exceso de fructosa se convierte en lípidos ejerciendo un efecto tóxico sobre el hígado, similar al producido por el exceso de alcohol, pudiendo provocar hígado graso no alcohólico (NAFLD). El objetivo de esta revisión es reunir hallazgos recientes en relación al efecto de la ingesta de fructosa en altas concentraciones y su relación con el NAFLD. Tipo: Journal article Palavras-chave: Hígado graso no alcohólico; Esteatohepatitis no alcohólica; Fibrosis hepática; Fructosa. Ano: 2017 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200047 Registros recuperados: 3 Primeira ... 1 ... Última

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